Dengue virus replication in cultures of peripheral blood leukocytes during the course of dengue haemorrhagic fever.
Southeast Asian J Trop Med Public Health
;
1975 Sep; 6(3): 316-21
Artigo
em Inglês
| IMSEAR
| ID: sea-33574
ABSTRACT
A preliminary study was made of the ability of cultured human peripheral blood leukocytes (PBL) to support dengue 2 infection. Leukocyte donors, children hospitalized with primary (one case) or secondary dengue infections (12 cases), were studied during the acute and convalescent stages of illness. D2 virus replication occurred infrequently in PBL cultures obtained from children before the 10th day after onset of symptoms (2/23 samples), but frequently thereafter (8/13 samples). The absence of virus permissive cells during the acute stage of illness might be explained by several different mechanisms, including the possibility that permissive PBL are exhausted as the result of a severe dengue infection. An unexpected finding was the appearance of dengue hemagglutination-inhibition antibodies in cultures of PBL obtained from children during the acute stage of secondary dengue infections.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tailândia
/
Replicação Viral
/
Humanos
/
Testes de Inibição da Hemaglutinação
/
Criança
/
Doença Aguda
/
Haplorrinos
/
Dengue
/
Vírus da Dengue
/
Lactente
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1975
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS