Promotion of aflatoxin B1-induced hepatocarcinogenesis by dichlorodiphenyl trichloroethane (DDT).
Southeast Asian J Trop Med Public Health
;
2002 Sep; 33(3): 613-23
Artigo
em Inglês
| IMSEAR
| ID: sea-34117
ABSTRACT
A study of the effect in rats of dichlorodiphenyl trichloroethane (DDT) on hepatocarcinogenesis that is initated by aflatoxin B1 (AFB1). In the first experiment, Buffalo rats were given a single oral dose of AFB1 (5 mg/kg) followed by dietary DDT (100 ppm) for 20 weeks. Neoplastic nodules were observed in 1 of the 14 AFB1-exposed rats, compared with 3 of the 19 rats in the AFB1/DDT group. In the second experiment, Wistar rats were given dietary aflatoxin B, (4 ppm) for 6 weeks followed by a 6-week exposure to DDT (500 ppm) in a plain semisynthetic diet. Five altered hepatic foci were displayed by seven rats in the AFB1 group, compared with 6 foci and one neoplastic focus in five of the AFB1/DDT rats at 32 weeks. Subsequently, the AFB1 group produced 8 (27.5%) tumor-bearing rats while 10 of the 28 (35.7%) AFB1/DDT-exposed rats were tumor-bearing by 60 weeks. The results suggest that DDT slightly potentiates hepatocarcinogenesis induced by either a single dose of AFB1 or short term-dietary AFB1.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ratos Endogâmicos BUF
/
Masculino
/
Carcinógenos
/
Distribuição Aleatória
/
Análise de Sobrevida
/
Aflatoxina B1
/
Ratos Wistar
/
Cocarcinogênese
/
DDT
Tipo de estudo:
Estudos de avaliação
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2002
Tipo de documento:
Artigo
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