In vitro studies on the sensitivity of local Entamoeba histolytica to anti-amoebic drugs.
Southeast Asian J Trop Med Public Health
;
1986 Dec; 17(4): 591-4
Artigo
em Inglês
| IMSEAR
| ID: sea-34287
ABSTRACT
The in vitro activity of drugs, namely dehydroemetine, ornidazole, metronidazole and tinidazole were determined against the locally isolated strains of E. histolytica in Thailand. The test was performed in liquid monophasic medium, i.e. liver marmite serum medium. In all, locally isolated strains from thirty hosts studied, the minimal inhibitory concentration (MIC) for dehydroemetine ranged from 0.125 to 1 microgram/ml, ornidazole ranged from 0.0625 to 0.25 microgram/ml, metronidazole ranged from 0.0625 to 0.125 microgram/ml, and tinidazole ranged from 0.0625 microgram/ml to 0.25 microgram/ml. The MIC of dehydroemetine was significantly different from ornidazole, metronidazole and tinidazole. Metronidazole was superior to that of dehydroemetine but was not significantly different among ornidazole, metronidazole and tinidazole.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ornidazol
/
Tinidazol
/
Resistência a Medicamentos
/
Emetina
/
Entamoeba histolytica
/
Amebicidas
/
Animais
/
Metronidazol
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1986
Tipo de documento:
Artigo
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