Antigenic types of Orientia tsutsugamushi in Malaysia.
Southeast Asian J Trop Med Public Health
;
2002 Sep; 33(3): 557-64
Artigo
em Inglês
| IMSEAR
| ID: sea-34458
ABSTRACT
The seroprevalence of various Orientia tsutsugamushi (OT) strains among Malaysian patients with suspected scrub typhus infections was determined using an indirect immunoperoxidase (IIP) assay. IgG against a single OT strain were detected in six sera (3 Karp, 1 Gilliam and 2 TC586), whereas IgM antibodies against a single OT strain (Gilliam) were noted in 3 sera (Gilliam). IgG reactive to all OT strains were present in 33 (47.1%) of the 70 sera and IgM reactive to all OT strains were present in 22 (78.6%) of the 28 sera. The fact that most sera were reactive to multiple OT strains suggests that group-specific antigens are involved in scrub typhus infections, whereas very few were due to strain-specific epitopes present on these strains. Peak IgG and IgM titers were noted more frequently against Gilliam, Karp, and TA763 strains this suggests that these strains may be the commonest infecting strains among Malaysian patients. Two predominant OT polypeptides consistently reacted with patients' sera were the 70 kDa and 56 kDa proteins.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Orientia tsutsugamushi
/
Humanos
/
Imunoglobulina G
/
Imunoglobulina M
/
Tifo por Ácaros
/
Immunoblotting
/
Estudos Soroepidemiológicos
/
Técnicas Imunoenzimáticas
/
Malásia
/
Antígenos de Bactérias
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2002
Tipo de documento:
Artigo
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