The use of monoclonal antibodies in the detection of circulating antigens in Malayan filariasis.
Southeast Asian J Trop Med Public Health
;
1993 ; 24 Suppl 2(): 23-5
Artigo
em Inglês
| IMSEAR
| ID: sea-34703
ABSTRACT
Wuchereria bancrofti, Brugia malayi and Brugia timori are the causative agents of lymphatic filariasis in Indonesia but in some endemic areas, B malayi is more commonly found. Diagnosis of filariasis is normally based on clinical, parasitological and immunological examinations but those methods have limitations. The discovery of monoclonal antibodies is expected to provide a new dimension to the efforts in the development of specific and sensitive immunological tests for the various stages of filariasis infection. This preliminary report, using monoclonal antibodies and dot-blot assay in human lymphatic filariasis showed that 75% of sera from microfilaremic patients with clinical signs, 40% of sera from amicrofilaraemic patients with clinical signs, 88.8% of sera from microfilaremic patients without clinical signs and 19.6% of sera from amicrofilaremic patients without clinical signs have circulating antigens.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Wuchereria bancrofti
/
Filariose Linfática
/
Brugia
/
Humanos
/
Prevalência
/
Brugia Malayi
/
Animais
/
Malásia
/
Anticorpos Monoclonais
/
Antígenos de Helmintos
Tipo de estudo:
Estudo diagnóstico
/
Estudo de prevalência
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1993
Tipo de documento:
Artigo
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