PCR can help early diagnosis of pulmonary tuberculosis.
Southeast Asian J Trop Med Public Health
;
2003 Mar; 34(1): 147-53
Artigo
em Inglês
| IMSEAR
| ID: sea-34760
ABSTRACT
One hundred and fifty-one patients, clinically suspected for pulmonary tuberculosis (age 31 +/- 13 years, male/female 112/39), were investigated to evaluate the diagnostic potential of polymerase chain reaction (PCR) based detection of the Mycobacterium tuberculosis complex in sputum. The diagnostic efficacy of PCR was compared with culture of Mycobacterium tuberculosis on egg-based Lowenstein-Jensen modified medium. PCR detected 71.5% (108/151), whereas culture detected 66.2% (100/151) of the clinically suspected patients. There was a significant association between the results of PCR and culture (chi2 = 59.524, p < 0.001). However, 23.2% (35/151) samples were found negative in both culture and PCR. Considering culture as the gold standard, the sensitivity of the PCR was 92%. and its specificity 70%. This lower apparent specificity may be due to the higher sensitivity of PCR.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Escarro
/
Tuberculose Pulmonar
/
Idoso de 80 Anos ou mais
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Distribuição de Qui-Quadrado
/
Reação em Cadeia da Polimerase
/
Sensibilidade e Especificidade
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Aged80
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2003
Tipo de documento:
Artigo
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