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Genotypes and subtypes of hepatitis B virus in Thailand.
Southeast Asian J Trop Med Public Health ; 1998 Dec; 29(4): 786-91
Artigo em Inglês | IMSEAR | ID: sea-34968
ABSTRACT
Hepatitis B virus exhibits considerable variability evident in its various antigenic subtypes, which complicates the characterization of epidemiological factors, particularly in areas endemic for hepatitis B. Our group investigated the genotypes and subtypes prevalent in Thailand employing nested PCR and sequencing of the a determinant, as well as the sub-determinants located on the S gene. The sera examined originated from a mixed range of HBV-infected individuals. The results were mostly consistent with those reported for Southeast Asia in that genotype C (54.4%) dominates over genotypes A (22.1%) and B1 (23.5%). Regarding the subtypes, we have exclusively found adw2 (45.6%) and adr (54.4%) as expected for this area, with one case of subtype adw representing the exception. While genotype and/or subtype of HBV do not predispose to clinical disease, they nevertheless may account for those few cases reported in which a mutation, particularly within the a determinant of the S gene, causes evasion of routine detection by commercial kits, particularly as long as the respective individuals remain asymptomatic carriers solely expressing anti-HBc.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Tailândia / Feminino / Humanos / Masculino / DNA Viral / Recém-Nascido / Vírus da Hepatite B / Transmissão Vertical de Doenças Infecciosas / Doenças Endêmicas / Genótipo País/Região como assunto: Ásia Idioma: Inglês Revista: Southeast Asian J Trop Med Public Health Ano de publicação: 1998 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Tailândia / Feminino / Humanos / Masculino / DNA Viral / Recém-Nascido / Vírus da Hepatite B / Transmissão Vertical de Doenças Infecciosas / Doenças Endêmicas / Genótipo País/Região como assunto: Ásia Idioma: Inglês Revista: Southeast Asian J Trop Med Public Health Ano de publicação: 1998 Tipo de documento: Artigo