The absence of antagonism between extracts of Clinacanthus nutans Burm. and Naja naja siamensis venom.
Southeast Asian J Trop Med Public Health
;
1977 Jun; 8(2): 249-54
Artigo
em Inglês
| IMSEAR
| ID: sea-35205
ABSTRACT
Clinacanthus nutans Burm, a herb reputed in Thailand and Malaysia to be "snakebite antidote" has been tested in vitro and in vivo for antivenin activity. The aqueous extract of C. nutans leaves has been found to have no effect on the inhibition of neuromuscular transmission produced by purified Naja naja siamensis neurotoxin in isolated rat phrenic-nerve diaphragm preparations. The extract of C. nutans, when given orally or intraperitoneally, are ineffective in prolonging the survival time of experimental mice receiving lethal doses of N.n. siamensis crude venom. Oral administrations of the herb extracts pretreated with alpha-amylase or beta-amylase also fail to protect the animal. It is concluded that the extract of C. nutans can not antagonize the action of cobra venom.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Nervo Frênico
/
Ratos
/
Mordeduras de Serpentes
/
Extratos Vegetais
/
Administração Oral
/
Proteínas Neurotóxicas de Elapídeos
/
Transmissão Sináptica
/
Venenos Elapídicos
/
Amilases
/
Injeções Intraperitoneais
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1977
Tipo de documento:
Artigo
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