The neurovirulence of flaviviruses in crab-eating monkeys (Macaca fascicularis).
Southeast Asian J Trop Med Public Health
;
1986 Dec; 17(4): 604-12
Artigo
em Inglês
| IMSEAR
| ID: sea-35566
ABSTRACT
The neurovirulent properties of attenuated dengue-2 and yellow fever (YF) vaccines, dengue-2 (DEN-2) and Japanese encephalitis (JE) viruses were studied in crab-eating monkeys (Macaca fascicularis). Number of central nervous system sites (as proportion affected) with neurovirulence (NV) lesions were compared. The results indicate that these monkeys reliably developed NV-lesion when inoculated with either JE or YF vaccine viruses (87%). NV-lesions occurred in a minority when inoculated with DEN-2 vaccine virus, were of minimal severity (9%), were probably biologically insignificant, and were of equal or less severity than lesions produced by its parental virus (10%).
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Virulência
/
Vírus da Febre Amarela
/
Feminino
/
Masculino
/
Vacinas Atenuadas
/
Vacinas Virais
/
Sistema Nervoso Central
/
Vírus da Dengue
/
Vírus da Encefalite Japonesa (Espécie)
/
Flavivirus
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1986
Tipo de documento:
Artigo
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