Molecular cloning of Plasmodium falciparum blood stage antigens and application of the recombinant proteins in serodiagnosis.
Southeast Asian J Trop Med Public Health
;
1992 Sep; 23(3): 402-5
Artigo
em Inglês
| IMSEAR
| ID: sea-35567
ABSTRACT
A Plasmodium falciparum genomic DNA library was established in the expression vector lambda gt11, cloned in Escherichia coli. The library was screened with human hyperimmune sera by in situ hybridization. Twenty clones expressing P. falciparum sequences as polypeptides fused to beta-galactosidase were identified. One, CD3A/9025/60, reacted with all immune sera and expressed polypeptides that were larger than beta-galactosidase as well as reacting with antibodies to beta-galactosidase and to P. falciparum. When the fusion proteins were used as target antigens to diagnose malaria antibodies, a result was obtained which correlated well with indirect fluorescence assay.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Plasmodium falciparum
/
Proteínas Recombinantes de Fusão
/
Humanos
/
DNA Recombinante
/
Testes Sorológicos
/
Biblioteca Genômica
/
Malária Falciparum
/
Clonagem Molecular
/
Genes de Protozoários
/
Estudos de Avaliação como Assunto
Tipo de estudo:
Estudo diagnóstico
/
Estudos de avaliação
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1992
Tipo de documento:
Artigo
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