Plasma level of diethylcarbamazine in jirds and hamsters.
Southeast Asian J Trop Med Public Health
;
1984 Mar; 15(1): 74-9
Artigo
em Inglês
| IMSEAR
| ID: sea-35688
ABSTRACT
The relation between the dosage and plasma level of diethylcarbamazine (DEC) in jirds and hamsters was examined by gas-liquid chromatography. When the drug was given intraperitoneally to jirds at 100 mg/kg body weight, the plasma level rose rapidly and reached the maximum level (20-25 micrograms/ml) at 10 minutes and afterwards fell quickly to undetectable level at 4 hours. Even if larger dosage (300 mg/kg) was given, DEC was eliminated completely from the blood circulation within 8 hours. When the same dosages of DEC were given intraperitoneally, the DEC levels remained 2-4 hours longer in the blood of hamsters than in the blood of jirds. DEC given by stomach intubation at 100 mg/kg remained detectable much longer in hamsters (8 hrs) than in jirds (2 hrs). A repeated doses schedule did not show a tendency for the drug to accumulate. DEC was excreted in the urine and feces, but the total amount of drug excreted without metabolic changes was only about 8% of the given dosage. The majority of unmetabolized DEC was excreted in the urine within 0-12 hours.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Administração Oral
/
Gerbillinae
/
Cricetinae
/
Dietilcarbamazina
/
Fezes
/
Injeções Intraperitoneais
/
Animais
Idioma:
Inglês
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
1984
Tipo de documento:
Artigo
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