Chemokines in Kawasaki disease: measurement of CCL2, CCL22 and CXCL10.

ABSTRACT

Kawasaki disease (KD) is a childhood-onset vascular disease. In order to determine whether KD is associated with altered chemokine production, we measured CCL2, CCL22, and CXCL10 levels in the serum of KD patients and healthy control subjects. The mean serum concentration of CCL2 in KD subjects was 829.0 +/- 388.2 pg/ml, significantly higher than that seen in healthy controls (223.4 +/- 92.6 pg/ml; p < 0.001). In addition, the mean serum CXCL10 level in KD subjects was 2,469.4 +/- 998.8 pg/ml, again significantly higher than that in healthy controls (127.7 +/- 64.2 pg/ml; p < 0.001). No difference was observed in serum concentrations of CCL22 between KD and healthy controls (1,685 +/- 1,985 microg/ml and 1,539 +/- 380 microg/ml, respectively). Thus, we observed the selective induction of a TH1-associated (CXCL10) and a TH2-associated chemokine (CCL2) in the serum of individuals with KD, suggesting a mixed TH1/TH2 response at the level of chemokine production and subsequent cell recruitment and thus pointing at a potential role for these chemokines in the pathology of KD.