Comparative study of the pharmacokinetic characteristics of slow release theophylline oral preparations in Thai children with persistent asthma.
Asian Pac J Allergy Immunol
;
1999 Dec; 17(4): 255-9
Artigo
em Inglês
| IMSEAR
| ID: sea-36591
ABSTRACT
Significant differences in the rate and extent of absorption exist between slow release theophylline (SRT) preparations. The pharmacokinetic characteristics of Xanthium were compared with those of Theo-Dur in twelve Thai children with stable persistent asthma by randomized, double blind, crossover study. Serum theophylline concentrations (STCs) were determined by fluorescence polarization immunoassay. The pharmacokinetic parameters were estimated by using a computer program (Topfit 2.0). The STCs, at steady state after different doses, were predicted by using the modified Wagner-Nelson Equation. The mean resident time (MRT) and apparent T1/2 were significantly larger for Xanthium, but the Cmax and AUC0-infinity of Xanthium were significantly lower than those of Theo-Dur. The Frel of Xanthium was 80.1% relative to Theo-Dur. The appropriate dosing interval of both preparations for Thai children was twice a day.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Asma
/
Tailândia
/
Teofilina
/
Software
/
Feminino
/
Humanos
/
Masculino
/
Criança
/
Método Duplo-Cego
/
Doença Crônica
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
1999
Tipo de documento:
Artigo
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