Antitumor mechanisms of Eubacterium lentum and its components.
Asian Pac J Allergy Immunol
;
1995 Dec; 13(2): 129-37
Artigo
em Inglês
| IMSEAR
| ID: sea-36671
ABSTRACT
In the present study, some antitumor mechanisms of Eubacterium lentum (TYH-11) and bacterial components having antitumor effects were investigated. E.lentum induced maximum NK cell activity in C3H/He mice on day 1 after injection (90.6% against 33.9% of control at ET ratio 501) and the activity was kept at a level of 48.6% on day 7. Tumoricidal peritoneal macrophages were induced 9 days after E.lentum injection into BALB/c mice (56.2% against 10.1% control at ET ratio 101). Tumoricidal macrophage activity persisted at the same level for at least 11 days. Cytotoxic T lymphocyte (CTL) activity was induced only in tumor bearing mice treated with E.lentum, 4 weeks after tumor inoculation. Antitumor activity was observed in the cell wall (CW) and membrane fractions (CM) of E.lentum. CW induced NK cell activity; the activity was transient while the kinetics of NK activity by CM showed 2 peaks, on day 1 and day 7. Tumoricidal macrophages were induced by CW and the activity level was the same as that induced by whole body, while that induced by CM was at a lower level. Neither CW nor CM induced CTL in tumor bearing mice.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Masculino
/
Inoculações Seriadas
/
Células Tumorais Cultivadas
/
Células Matadoras Naturais
/
Adjuvantes Imunológicos
/
Macrófagos Peritoneais
/
Citotoxicidade Imunológica
/
Eubacterium
/
Animais
/
Camundongos
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
1995
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS