Specific IgA antibody to Epstein-Barr viral capsid antigen: a better marker for screening nasopharyngeal carcinoma than EBV-DNA detection by polymerase chain reaction.
Asian Pac J Allergy Immunol
;
2000 Dec; 18(4): 221-6
Artigo
em Inglês
| IMSEAR
| ID: sea-36754
ABSTRACT
Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection. To assess whether EBV DNA detection by polymerase chain reaction (PCR) or presence of specific serum antibody to viral capsid antigen (VCA) was a better marker for screening NPC, nasopharyngeal tissues and blood samples from 58 NPC patients and 24 non-NPC patients (23 with laryngotracheal stenosis and 1 with chronic tonsillitis) were tested for the presence of EBV DNA and serum specific VCA antibodies, respectively. EBV DNA was detected in 56 (96.5%) of NPC patients and 15 (62.5%) of non-NPC controls, with predominantly EBV type A in both groups. On the other hand, specific VCA IgA antibody was detected in the majority of NPC patients 52 (89.7%) while only 4 (16.7%) were detected in non-NPC controls. Therefore, specific VCA IgA antibody may serve as a better marker for screening NPC than EBV DNA detected by PCR.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
DNA Viral
/
Imunoglobulina A
/
Biomarcadores
/
Programas de Rastreamento
/
Neoplasias Nasofaríngeas
/
Reação em Cadeia da Polimerase
/
Valor Preditivo dos Testes
/
Sensibilidade e Especificidade
/
Infecções por Vírus Epstein-Barr
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
2000
Tipo de documento:
Artigo
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