Lymphocyte subset T4/T8 ratio in systemic lupus erythematosus: correlation with disease activity, laboratory abnormalities and treatment.
Asian Pac J Allergy Immunol
;
1988 Jun; 6(1): 23-8
Artigo
em Inglês
| IMSEAR
| ID: sea-36977
ABSTRACT
Lymphocyte subsets were studied in forty-nine patients with SLE using monoclonal antibodies and flow cytometry. A decrease in T4+ reactive cells (helper/inducer) was the most frequent observation. Decreased T4/T8 ratios were seen in patients with increasing clinically active disease, patients with positive anti-DS-DNA, positive anti-RNP antibodies and patients with low CH50 activity. However, low T4/T8 ratios were seen in patients with negative anti-Sm. Low T4/T8 ratios were also observed in patients taking prednisone at more than 10 mg/day and in patients treated with immunosuppressive drugs.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Prednisona
/
Linfócitos T
/
Linfócitos T CD4-Positivos
/
Adolescente
/
Adulto
/
Imunossupressores
/
Lúpus Eritematoso Sistêmico
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
1988
Tipo de documento:
Artigo
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