Renin angiotensin aldosterone system and drug allergies complicated with hypotension.
Asian Pac J Allergy Immunol
;
2000 Jun; 18(2): 81-3
Artigo
em Inglês
| IMSEAR
| ID: sea-37020
ABSTRACT
It has been discussed in several studies that non-immunologic factors, such as renin angiotensin aldosterone system (RAAS) may play a role in the pathophysiology of anaphylaxis. This study aimed to determine whether RAAS plays a part in the fall in blood pressure during drug reactions or not. Twenty patients who experienced hypotension during drug reaction and 15 healthy volunteers were enrolled in this study. None of the patients in the study or control groups were under treatment with any drug that was capable of influencing to RAAS. Serum levels of angiotensin-I (A-I), angiotensin-II (A-II), angiotensin converting enzyme (ACE) and aldosterone were measured in both study and control groups. The Mann-Whitney U test was used to compare the results of the groups. There were no statistically significant differences between the groups with respect to A-I, A-II, ACE and aldosterone levels. It was concluded that a fall in blood pressure during drug reaction must be the result of mast cell mediator effects on the vascular wall rather than RAAS impairment.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Sistema Renina-Angiotensina
/
Feminino
/
Humanos
/
Masculino
/
Angiotensina I
/
Angiotensina II
/
Estudos de Coortes
/
Adolescente
/
Peptidil Dipeptidase A
/
Estatísticas não Paramétricas
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
2000
Tipo de documento:
Artigo
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