Evaluation of human IgG subclass antibodies in the serodiagnosis of Paragonimiasis heterotremus.
Asian Pac J Allergy Immunol
;
2005 Dec; 23(4): 205-11
Artigo
em Inglês
| IMSEAR
| ID: sea-37051
ABSTRACT
Immunoglobulin G subclass antibodies (IgG1, IgG2, IgG3, and IgG4) responses to the excretory-secretory antigens of the lung fluke, Paragonimus heterotremus, were analyzed using the immunoblotting technique in an attempt to further improve the sensitivity and specificity for serodiagnosis of human paragonimiasis. Serum samples from patients with proven paragonimiasis, from patients with other parasitic infections, pulmonary tuberculosis and from healthy counterparts were analyzed. The results indicate that immunoblotting for the detection of IgG4 antibodies to an excretory-secretory product of P. heterotremus of an approximate molecular mass of 31.5 kDa, is the most reliable test. It gives accuracy, sensitivity, specificity, and positive and negative predictive values of 97.6%, 100%, 96.9%, 90% and 100%, respectively.
Texto completo:
DisponíveL
Índice:
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Assunto principal:
Paragonimíase
/
Paragonimus
/
Humanos
/
Imunoglobulina G
/
Testes Sorológicos
/
Sensibilidade e Especificidade
/
Adulto
/
Animais
/
Antígenos de Helmintos
Tipo de estudo:
Estudo diagnóstico
/
Estudos de avaliação
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
2005
Tipo de documento:
Artigo
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