The effects of Porphyromonas gingivalis LPS and Actinobacillus actinomycetemcomitans LPS on human dendritic cells in vitro, and in a mouse model in vivo.
Asian Pac J Allergy Immunol
;
2006 Dec; 24(4): 223-8
Artigo
em Inglês
| IMSEAR
| ID: sea-37098
ABSTRACT
Interaction between different bacterial plaque pathogens and dendritic cells may induce different types of T helper (Th) cell response, which is critical in the pathogenesis of periodontitis. In this study we investigated the effects of lipopolysaccharide (LPS) from Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans on human monocyte-derived dendritic cells (Mo-DCs) with respect to co-stimulatory molecule expression, cytokine production and Th cell differentiation. Unlike Escherichia coli and A. actinomycetemcomitans LPS, P. gingivalis LPS induced only low levels of CD40, CD80, HLA-DR and CD83 expression on Mo-DCs. LPS from both bacteria induced considerably lower TNF-alpha and IL-10 than did E. coli LPS. LPS from all three bacteria induced only negligible IL-12 production. In a human mixed-leukocyte reaction, and in an ovalbumin-specific T cell response assay in mice, both types of LPS suppressed IFN-gamma production. In conclusion, stimulation by P. gingivalis LPS and A. actinomycetemcomitans LPS appears to bias Mo-DCs towards Th2 production.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Células Dendríticas
/
Humanos
/
Antígenos de Diferenciação
/
Diferenciação Celular
/
Células Cultivadas
/
Lipopolissacarídeos
/
Citocinas
/
Aggregatibacter actinomycetemcomitans
/
Porphyromonas gingivalis
/
Células Th2
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
2006
Tipo de documento:
Artigo
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