Expression of c-erbB-2 oncoprotein in primary human tumors: an immunohistochemistry study.
Asian Pac J Allergy Immunol
;
1993 Dec; 11(2): 119-22
Artigo
em Inglês
| IMSEAR
| ID: sea-37172
ABSTRACT
An immunohistochemical study was performed with 130 primary malignant human tumors of breast (n = 55)..colon/rectum (n = 16), stomach (n = 19), esophagus (n = 14), lung (n = 15) and liver (n = 11) using the 21N c-erbB-2 specific monoclonal antibody to identify the tumors that over-expressed the c-erbB-2 oncoprotein. Positivity appeared as an intense brown granular staining located predominantly at the cell membrane. This occurred in 41.8% of breast carcinomas, 12.5% of colorectal adenocarcinomas. None of the gastric adenocarcinomas, squamous cell carcinomas of the esophagus, small cell lung carcinomas or hepatocellular carcinomas were positive for the oncoprotein. The result of this study suggests that over-expression of the c-erbB-2 oncoprotein is common in breast cancer and relatively rare in other malignancies examined.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias da Mama
/
Feminino
/
Humanos
/
Neoplasias Colorretais
/
Biomarcadores Tumorais
/
Técnicas Imunoenzimáticas
/
Proteínas Proto-Oncogênicas
/
Receptor ErbB-2
/
Receptores ErbB
/
Anticorpos Monoclonais
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
1993
Tipo de documento:
Artigo
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