Soluble interleukin-2 receptor as a clinical parameter for nasopharyngeal carcinoma.
Asian Pac J Allergy Immunol
;
1995 Jun; 13(1): 1-4
Artigo
em Inglês
| IMSEAR
| ID: sea-37173
ABSTRACT
We evaluated whether the serum soluble interleukin-2 receptor (sIL-2R) may be a parameter to monitor the efficacy of treatment for nasopharyngeal carcinoma (NPC). There were 177 NPC patients and 24 healthy controls. The level of sIL-2R was measured with a sandwich ELISA kit. Higher levels of sIL-2R than for controls were found in NPC patients before treatment and in patients with distant metastasis (p < 0.001). There was, however, no difference in sIL-2R levels between controls and NPC patients after radiotherapy in relapse-free or in primary relapse. The sIL-2R levels in sequential testing revealed good correlation with clinical response. The sIL-2R levels were found to be elevated when distant metastasis was detected. Two patients had elevated sIL-2R level up to 5 months before clinical detection of metastasis. These results indicate that serial measurements of sIL-2R levels are worthwhile for NPC patients in their clinical course. The sIL-2R level proved to be an adjunct clinical parameter to monitor the efficacy of treatment of NPC.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Receptores de Interleucina-2
/
Biomarcadores Tumorais
/
Neoplasias Nasofaríngeas
/
Estudos Retrospectivos
/
Resultado do Tratamento
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
1995
Tipo de documento:
Artigo
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