Cell-mediated immunosuppression in mice by street rabies virus not restored by calcium ionophore or PMA.
Asian Pac J Allergy Immunol
;
1997 Sep; 15(3): 127-32
Artigo
em Inglês
| IMSEAR
| ID: sea-37184
ABSTRACT
It is known that rabies virus can suppress the host immune system. In this study we demonstrate a depression of cell-mediated immunity in mice, peripherally infected with Thai street rabies virus. The cell-mediated cytolysis of spleen cells from mice increased transiently on day 5 after infection and declined rapidly thereafter until death. The proliferation of spleen cells stimulated with a T-cell mitogen such as phytohemagglutinin or concanavalin A, was significantly suppressed during the course of infection. There was also a marked suppression of IL-2 secretion in parallel with a decrease of the T-cell proliferative response to mitogen. The suppression of T-cell proliferation was not restored by treatment with a calcium ionophore (A 23187) or phorbol 12-myristate-13 acetate (PMA).
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Raiva
/
Vírus da Raiva
/
Proteína Quinase C
/
Acetato de Tetradecanoilforbol
/
Ativação Linfocitária
/
Linfócitos T
/
Cátions Bivalentes
/
Cálcio
/
Calcimicina
/
Terapia de Imunossupressão
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
1997
Tipo de documento:
Artigo
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