Plasma endothelin-1 in infants and young children with acute bronchiolitis and viral pneumonia.
Asian Pac J Allergy Immunol
;
2002 Dec; 20(4): 229-34
Artigo
em Inglês
| IMSEAR
| ID: sea-37214
ABSTRACT
Respiratory syncytial virus (RSV) Infections that occur during the first three years of life have been demonstrated to be associated with the development of childhood asthma. The mechanism of virus-triggered airway inflammation Is not fully understood. Endothelin-1 is a potent bronchoconstrictor involved in many diseases including respiratory tract infections. Infants and young children diagnosed with either viral pneumonia or acute bronchiolitis, their age ranging between 2 months and 3 years, were recruited into this study. Nasopharyngeal aspirates were taken for detection of respiratory virus by antigen immunofluorescence stain, RT-PCR analysis and viral culture. Plasma endothelin-1 (ET-1) was measured by using a commercially available enzyme-linked immunosorbent assay (ELISA). Ten of the nineteen infants and children (52%) were positive for RSV infection, one co-infected with influenza A. Nine Infants (90%) were positive for RSV subtype A. There was only one infant with subtype B. One of the RSV negative individuals was positive for influenza A. In addition, we recruited 10 patients without chronic underlying or respiratory tract illness as controls. ET-1 levels were significantly increased in RSV infection compared to the controls (3.6 +/- 1.2 and 1.2 +/- 1 pg/ml, respectively (p < 0.05). In conclusion, infants and young children who are infected with RSV have an increase in circulating plasma endothelin-1. This in turn may contribute to the subsequent development of childhood asthma.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pneumonia Viral
/
Infecções Respiratórias
/
Feminino
/
Humanos
/
Masculino
/
Recém-Nascido
/
Ensaio de Imunoadsorção Enzimática
/
Bronquiolite
/
Criança
/
Pré-Escolar
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Asian Pac J Allergy Immunol
Ano de publicação:
2002
Tipo de documento:
Artigo
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