Effect of demographic and clinicopathologic factors on prognosis of early gastric cancer in Iran.

ABSTRACT

BACKGROUND: The aim of this study was to estimate some prognostic factors that affect on overall survival of patients with early gastric cancer. METHODS: A retrospective study had been done on patients diagnosed with early gastric cancer who registered in cancer registry center, Tehran, Iran, between December 21, 2001 and December 21, 2006 and all patients were followed by telephone contacts. The Kaplan-Meier method was performed to describe survival curves and log-rank test to compare the survival rate in subgroups. Cox regression was used to determine the prognosis factors. RESULTS: The mean age was 57.9 years and 72.6% of patients were male. Tumor size (>35 mm) and lymph node metastasis were established as significant factors for survival of patients with EGC in both univariate and multivariate analysis. CONCLUSION: The findings of this study indicate that lymph node metastasis and tumor size are the most independent prognostic factors in these patients.