Environmental factors related to gastric cancer associated with Epstein-Barr virus in Colombia.
Artigo
em Inglês
| IMSEAR
| ID: sea-37791
ABSTRACT
Epstein-Barr virus (EBV)-encoded small RNA can be detected in about 1-17 % of gastric carcinomas. To elucidate lifestyles and other factors related to such an EBV-associated gastric carcinoma (EBV-GC), we conducted a case-control study in Cali, Colombia. The study subjects were 368 patients with gastric carcinoma newly diagnosed during the period between September 2000 and June 2003, including 42 EBV-GC cases. We obtained information on lifestyles, dietary habits, and occupational exposure by a questionnaire. The frequency of EBV-GC was related to birth order of patients (P for trend =0.025). More precisely, EBV-GC was much less frequent among the patients who were the eldest child in a family (P=0.007). Those findings were contrary to what was reported by the study conducted in Japan, where EBV-GC was more frequently observed among eldest brothers/sisters. A possible explanation for the apparently conflicting results is that EBV-GC risk is related to the age at first EBV infection but its relationship is not monotonic. In addition to the relationship with birth order, the present study showed that high salt intake and metal dust exposure may be related to EBV-GC as reported by the Japanese study although these associations observed in the present study were not statistically significant. No significant association was observed in other factors, including dietary habits. Further studies seem warranted to elucidate the difference between Japan and Colombia with respect to the environmental factors related to EBV-GC cases.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias Gástricas
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Estudos de Casos e Controles
/
Ordem de Nascimento
/
Inquéritos e Questionários
/
Fatores de Risco
/
Exposição Ocupacional
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
País/Região como assunto:
América do Sul
/
Colômbia
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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