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Real-time quantitative PCR analysis of amplified DNA on chromosomes 4p15.2 and 6q23-24 from formalin-fixed, paraffin-embedded breast cancer tissues.
Artigo em Inglês | IMSEAR | ID: sea-37838
ABSTRACT
This study was performed to detect amplification of DNA sequences on chromosomes 4p15.2 and 6q23-24, obtained from formalin-fixed, paraffin-embedded, breast-cancer tissues. The prognostic relevance of the amplification was also demonstrated. DNA from formalin-fixed, paraffin-embedded tumor and corresponding normal tissues of 53 patients with breast cancer was extracted and amplified by real-time quantitative PCR technique. Amplification of the DNA sequences on chromosomes 4p15.2 and 6q23-24 was detected in 23 (43%) and 32 (60%) cases, respectively. Thirty-six (68%) cases showed amplification on both or one of the chromosomes. These frequencies are similar to that obtained from fresh samples in our previous study. In addition, amplification of the DNA on chromosomes 4p15.2 and / or 6q23-24 was predominantly observed in tumors with invasive ductal carcinoma. The findings in this study demonstrate that DNA extracted from formalin-fixed, paraffin-embedded breast tumors can be used to determine amplification of DNA sequences on selective chromosomal regions. We also suggest that the amplified DNA on chromosomal regions 4p15.2 and 6q23-24 might be involved in the development and progression of breast cancer.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Cromossomos Humanos Par 4 / Cromossomos Humanos Par 6 / Neoplasias da Mama / Feminino / Humanos / DNA de Neoplasias / Análise Mutacional de DNA / Amplificação de Genes / Reação em Cadeia da Polimerase / Aberrações Cromossômicas Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Cromossomos Humanos Par 4 / Cromossomos Humanos Par 6 / Neoplasias da Mama / Feminino / Humanos / DNA de Neoplasias / Análise Mutacional de DNA / Amplificação de Genes / Reação em Cadeia da Polimerase / Aberrações Cromossômicas Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2007 Tipo de documento: Artigo