Immunoglobulin heavy and light chain isotypes in multiple myeloma patients.
Artigo
em Inglês
| IMSEAR
| ID: sea-37841
ABSTRACT
The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myeloma proteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patients samples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniques in this study. We found that majority of the myeloma proteins (58%) were of the IgG isotype followed by IgA (24%) and biclonal gammopathy associated with IgG and IgA (5%). Both kappa and lambda light chains were associated with the heavy chain isotypes. We recommend the triangular combination for detection of M-proteins and biclonal gammopathy of cancerous plasma cells as biomarkers for diagnosis of myeloma.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Humanos
/
Imunoglobulinas
/
Ensaio de Imunoadsorção Enzimática
/
Imunoeletroforese
/
Cadeias Pesadas de Imunoglobulinas
/
Cadeias Leves de Imunoglobulina
/
Mieloma Múltiplo
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2007
Tipo de documento:
Artigo
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