Epithelial ovarian cancer at a cancer hospital in a developing country.

ABSTRACT

OBJECTIVES: To analyze records of patients seen with malignant epithelial ovarian cancer at a tertiary care cancer hospital in Pakistan and obtain information on factors as laterality, histology, CA-125 levels, and stage of the disease, determine age at presentation and, assess menopausal status of the patients. Also, to review results obtained in light of data published in indexed journals. PATIENTS AND METHODS: We analyzed 544 cases of malignant ovarian epithelial tumors registered at the Shaukat Khanum Memorial Cancer Hospital and Research Center from December 1994-December 2003. RESULTS: Mean age at presentation 48.1 years (SD 13, range 4-82 years); commonest histological sub-type serous cystadenocarcinoma (28.6%); most frequently seen stage 3 (43.5%), followed by stage 4 (22.4%); post-menopausal 56.8% of the women; bilateral disease 41.2% of the women; and Cancer Antigen-125 (CA-125) level elevated in 70% of the females. CONCLUSIONS: Stage at presentation in majority of the cases was advanced as compared to that seen in the west. With only minor variations, our findings seem consistent with those reported in other local studies. However, it is imperative to conduct an extensive population-based study to understand the impact of, and develop strategies for the management of ovarian cancer in Pakistan.