Acute hepatitis associated with Barakol.
Artigo
em Inglês
| IMSEAR
| ID: sea-38332
ABSTRACT
Barakol is a natural anxiolytic extracted from Cassia siamea, known as "Khi-lek" in Thailand. The authors studied the adverse effects of Barakol in 12 healthy Thai patients, aged 29-81 years (mean 52.5) who took Barakol 3-180 days (mean 76.9). Eight of them were admitted with the first episode of anorexia and jaundice for 4-60 days (mean 14.3) after taking 20-40 mg/day (2-4 tablets) of Barakol. There was no relationship between degree of symptom and dosage/duration of Barakol intake. Three asymptomatic cases were detected with increased aminotransferase from a routine check-up, including an 81 year old female who took half of the dosage for 120 days. The last one was a male patient who presented with low-grade fever and nausea and vomiting. All patients had neither a history of chronic liver disease nor known hepatotoxic substance ingestion. On admission, the mean total bilirubin was 5.7 mg/dl and liver function test (LFT) revealed moderate to severe hepatitis (Aspartate amino transferase (AST) range 111-1,473 U/L mean = 692). None of them had detected viral markers. Liver biopsy was done in 3 cases and the histopathological findings were compatible with interface hepatitis. Two non-biopsy cases developed recurrent transaminitis after one-week re-challenging without informing the physician. Their symptoms and LFT completely improved within 2-20 weeks (mean 5.9) after Barakol abstinence.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Benzopiranos
/
Idoso de 80 Anos ou mais
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Doença Aguda
/
Estudos Retrospectivos
/
Adulto
/
Fenalenos
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Aged80
Idioma:
Inglês
Ano de publicação:
2003
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS