Lack of effect of Helicobacter pylori on symptom improvement with a prokinetic medication, cisapride, in patients with non-ulcer dyspepsia.
Artigo
em Inglês
| IMSEAR
| ID: sea-39053
ABSTRACT
OBJECTIVE:
This study was undertaken to determine whether H. pylori infection has an effect on the improvement of dyspeptic symptoms in response to a prokinetic agent, cisapride, in patients with non-ulcer dyspepsia (NUD). MATERIAL ANDMETHOD:
35 NUD patients (16 M, 19 F) who had no underlying medical condition and negative upper endoscopy were included in the present study. Each patient received a 2-wk treatment of cisapride (Prepulsid, 10 mg, tid ac). H. pylori infection was determined using a rapid urease test (CLO test). Gastric emptying (GE) scintigraphy and dyspeptic symptom scores were evaluated before and at the end of the treatment. GE was evaluated in 22 healthy volunteers as normal controls.RESULTS:
Half time (T1/2) GE of NUD patients was 90.9 +/- 28 min which was significantly longer than controls (77.6 +/- 14 min; p < 0.05) and was shortened to 73.6 +/- 22 min (p < 0.0001) at the end of the treatment. Cisapride significantly improved total dyspeptic symptom scores [7 (2-18) to 3 (0-11), p < 0.0001]. The symptom score improvement was not affected by H. pylori infection [H. pylori positive 6 (2-18) to 2.5 (0-9), p < 0.0001; H. pylori negative 9 (4-16) to 3 (0-11), p < 0.0001] or GE status [delayed GE 10 (5-16) to 3 (15), p < 0.05; non delayed GE 6 (2-18) to 2 (0-11); p < 0.0001].CONCLUSIONS:
Cisapride improves dyspeptic symptoms regardless of H. pylori and GE status. These results suggest that gastric emptying and H. pylori infection are not essential to determine prior to prescribing a prokinetic agent, cisapride, in patients with NUD.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fármacos Gastrointestinais
/
Feminino
/
Humanos
/
Masculino
/
Esquema de Medicação
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Resultado do Tratamento
/
Agonistas Colinérgicos
/
Adulto
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Ano de publicação:
2005
Tipo de documento:
Artigo
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