Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m2/day.
Artigo
em Inglês
| IMSEAR
| ID: sea-39492
ABSTRACT
OBJECTIVE:
Evaluate the efficacy and the tolerability of preoperative chemoradiation with high dose Capecitabine. MATERIAL ANDMETHOD:
Fifteen patients with locally advanced resectable rectal cancer were treated with Capecitabine 2,000 mg/m2/day, orally 7 days/week concurrent with whole pelvic irradiation 45 Gy in 25 fractions/5 weeks. Patients underwent surgery in the following 4-6 weeks.RESULTS:
After complete treatment, 11 patients (73%) underwent surgery. Ten patients (66%) had sphincter preservative surgery; three of them had primary tumors located in the lower rectum. Five patients had grade 2 and one patient had grade 3 diarrhea. No grade 4 toxicity was reported.CONCLUSION:
Preoperative Capecitabine 2,000 mg/m2/day concurrent with whole pelvic irradiation were effective and well tolerated The potential dose limiting toxicity effect was the diarrhea.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Complexo Vitamínico B
/
Idoso
/
Cuidados Pré-Operatórios
/
Feminino
/
Humanos
/
Masculino
/
Neoplasias Colorretais
/
Leucovorina
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Quimioterapia Adjuvante
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Progressão da Doença
Idioma:
Inglês
Ano de publicação:
2008
Tipo de documento:
Artigo
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