Hb G Makassar (beta 6:Glu-Ala) in a Thai family.
Artigo
em Inglês
| IMSEAR
| ID: sea-39629
ABSTRACT
Hemoglobin G Makassar was identified in a family of Thai origin, which was found to share identical properties with hemoglobin S in routine hemoglobin separation both by cellulose acetate electrophoresis and cation-exchange HPLC. It is, therefore, subjects with hemoglobin G Makassar and hemoglobin S who may sometimes be mistakenly identified for each other. In this study, identification of hemoglobin G Makassar was achieved by DNA sequence analysis, which revealed a single nucleotide substitution GAG-->GCG at codon 6 of the beta-globin gene. The hemoglobin variant was hemoglobin G Makassar [beta 6Glu-->Ala]. This is the first report of hemoglobin G Makassar in Thailand.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tailândia
/
Feminino
/
Humanos
/
Globinas
/
Hemoglobinas Anormais
/
Gravidez
/
Cromatografia Líquida de Alta Pressão
/
Análise de Sequência de DNA
/
Ácido Glutâmico
/
Adulto
Tipo de estudo:
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2002
Tipo de documento:
Artigo
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