Histomorphological study of indomethacin induced gastrointestinal lesions in rat.
Bangladesh Med Res Counc Bull
;
1993 Dec; 19(3): 94-8
Artigo
em Inglês
| IMSEAR
| ID: sea-397
ABSTRACT
This study was undertaken in Long Evans rat to investigate the effect of a single therapeutic as well as toxic dose of indomethacin on the gastrointestinal mucosa. The effect was studied morphologically six hours after oral administration of the drug. The affected tissue was then examined histologically. The histomorphological evaluation revealed that the drug has induced acute hemorrhagic erosive gastritis in the fasted animals (6 mg/Kg body weight) where as in normally fed (10 mg/kg body weight) rats the small intestinal mucosal inflammation and erosions were predominant.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ratos Endogâmicos
/
Feminino
/
Masculino
/
Indometacina
/
Administração Oral
/
Relação Dose-Resposta a Droga
/
Mucosa Gástrica
/
Gastrite
/
Mucosa Intestinal
Idioma:
Inglês
Revista:
Bangladesh Med Res Counc Bull
Ano de publicação:
1993
Tipo de documento:
Artigo
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