The incidence of K-ras codon 12 mutations in cholangiocarcinoma detected by polymerase chain reaction technique.
Artigo
em Inglês
| IMSEAR
| ID: sea-40215
ABSTRACT
In the study, to analyse a K-ras oncogene mutated at codon 12 in 24 patients with cholangiocarcinomas, four (16.67%) of them contained this point mutation. One of 4 was peripheral and the others were hilar tumors. There was no significant relationship between mutation and clinical features in terms of age, sex, endemic area, tumor location, tumor grading and pathological features. In our study, the incidence of K-ras codon 12 mutation in Thai patients with cholangiocarcinoma was lower than that found in British and Japanese patients. The discrepancy of incidence and type of the mutations, in different races and environment probably indicates that there is/are different etiologic mechanism(s) in the pathogenesis of cholangiocarcinoma.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias dos Ductos Biliares
/
Ductos Biliares Intra-Hepáticos
/
Idoso de 80 Anos ou mais
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Códon
/
DNA de Neoplasias
/
Dados de Sequência Molecular
Tipo de estudo:
Estudo diagnóstico
/
Estudo de incidência
Limite:
Aged80
Idioma:
Inglês
Ano de publicação:
1998
Tipo de documento:
Artigo
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