D-dimer and pulmonary arterial hypertension in systemic sclerosis.
Artigo
em Inglês
| IMSEAR
| ID: sea-40316
ABSTRACT
BACKGROUND:
Micro-vascular thrombus is a common pathological finding in pulmonary artery hypertension. The association between plasma D-dimer, a marker of thrombus formation, and pulmonary artery hypertension (PAH) in patients with systemic sclerosis is unknown.OBJECTIVE:
To assess the correlation of the level of plasma D-dimer and pulmonary artery pressure in patients with systemic sclerosis. MATERIAL ANDMETHOD:
One hundred and twenty nine patients with systemic sclerosis between 19 and 75 years of age (mean, 48 +/- 11.3) entered the study. Plasma D-dimer was determined using immunoturbidimetric assay (D-dimer plus, Dade Behring Inc., Newark, USA). Pulmonary artery pressure was estimated by Doppler echocardiography. PAH was considered present if the Doppler echocardiography-estimated right ventricular systolic pressure (RVSP) exceeded 36 mmHg.RESULTS:
Forty-seven patients (36.4%) had PAH according to Doppler echocardiography including 32 (68.1 %) mild (RVSP, 36-45 mmHg), nine (19.1%) moderate (RVSP, 46-55 mmHg), and six (12.8%) severe PAH (RVSP > or = 56 mmHg). No significant correlation was found between plasma D-dimer and RVSP (r = 0. 02, p = 0. 82).CONCLUSION:
The present study demonstrated that the D-dimmer level is not associated with the level of pulmonary artery pressure in patients with systemic sclerosis, indicating that microvascular thrombosis may not play a significant role in the pathogenesis of PAH in patients with systemic sclerosis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Artéria Pulmonar
/
Escleroderma Sistêmico
/
Índice de Gravidade de Doença
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Produtos de Degradação da Fibrina e do Fibrinogênio
/
Biomarcadores
/
Estudos Prospectivos
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Ano de publicação:
2007
Tipo de documento:
Artigo
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