No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells.
Artigo
em Inglês
| IMSEAR
| ID: sea-40730
ABSTRACT
Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Imuno-Histoquímica
/
Carcinoma in Situ
/
Neoplasias Colorretais
/
Antígenos de Histocompatibilidade Classe I
/
Pólipos Adenomatosos
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Antígenos HLA
Idioma:
Inglês
Ano de publicação:
2004
Tipo de documento:
Artigo
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