5-fluorouracil and mitomycin-C: effective, low-cost chemotherapy for colorectal cancer.
Artigo
em Inglês
| IMSEAR
| ID: sea-41383
ABSTRACT
OBJECTIVE:
To evaluate the regimen of 5-fluorouracil (5-FU) and mitomycin-C (MMC) in terms ofresponse rate and overall survival in advanced colorectal cancer. MATERIAL ANDMETHOD:
Between January 1993 and December 2000, 121 from 559 patients with advanced colorectal cancer were treated with chemotherapy. Bolus MMC (10 mg/m2) on first day, 5-FU (600 mg/m2/day) was given as a continuous infusion for 5 days, repeated every 4 weeks for 6 cycles. Toxicity and response were analyzed according to WHO criteria, and survival was analyzed according to Kaplan-Meier methodology.RESULTS:
In the chemotherapy group (121 patients), 70 were males and 51 were females, the mean age was 52 years. The ratio of colon and rectal cancer was 0.57. Nearly all patients (88.89%) had tumors with moderate differentiation. Forty patients with liver metastasis showed an overall response rate of 45% (95% CI 35.4-54.6) with a CR in 3 (7.5%) and PR in 15 (37.5%). The median survival was 13.1 months. The regimen was well tolerated with 11.64% of patients experiencing WHO grade 3-4 toxicity.CONCLUSION:
The present study has indicated a highly active, acceptable toxic, inexpensive regimen of old drugs to be used as an alternative to the more expensive combination including CPT-11 or oxaliplatin.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Compostos Organoplatínicos
/
Feminino
/
Humanos
/
Masculino
/
Camptotecina
/
Esquema de Medicação
/
Neoplasias Colorretais
/
Protocolos de Quimioterapia Combinada Antineoplásica
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Taxa de Sobrevida
/
Estudos Retrospectivos
Tipo de estudo:
Avaliação Econômica em Saúde
/
Estudo observacional
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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