DNA typing of the HLA-A, -B and -C genes: possible MHC class I haplotypes in the northeastern-Thais.
Artigo
em Inglês
| IMSEAR
| ID: sea-41625
ABSTRACT
The phenotype and gene frequencies of HLA class I were studied in the Northeastern Thai population. Blood samples were collected from 100 unrelated healthy northeastern-Thais. HLA-A, -B and -Cw alleles were determined using the polymerase chain reaction- amplification refractory mutation system (PCR-ARMS). 12 HLA-A, 20 HLA-B and 14 HLA-Cw alleles were found. Linkage disequilibrium analysis indicated the existence of 7 HLA-A-B and 19 HLA-B-Cw haplotypes. A*0207-Cw*01-B*4601 was the most common possible haplotype in this population. These results provide regional basic information for further studies in anthropology, organ transplantation and MHC disease associations in the northeastern-Thais.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fenótipo
/
Polimorfismo Genético
/
Tailândia
/
Haplótipos
/
Humanos
/
Antígenos HLA-A
/
Antígenos HLA-B
/
Antígenos HLA-C
/
Etnicidade
/
Distribuição de Qui-Quadrado
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
1997
Tipo de documento:
Artigo
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