Effects of combined sildenafil-nitric oxide donor on defibrillation efficacy.
Artigo
em Inglês
| IMSEAR
| ID: sea-42700
ABSTRACT
BACKGROUND:
A previous study demonstrated that supra-therapeutic concentration of sildenafil citrate attenuates defibrillation efficacy. However, the effect of combined sildenafil and NTG administration on defibrillation efficacy is not known.OBJECTIVE:
The present study investigated whether sildenafil administration at the therapeutic level increases the defibrillation threshold (DFT) when combined with NTG. MATERIAL ANDMETHOD:
Twenty-four pigs (20-25 kg) were randomized into four groups. After the control DFT was obtained, a stock solution of 50-mg (group 1, therapeutic concentration) and 100-mg (group 2, supratherapeutic concentration) of sildenafil, and 100-mL of saline (groups 3 and 4) were infused at 2 mL/min. Then, NTG was administered in groups 1-3 at 5 microg/min, with an increment of 5 microg/min every 5 min. The DFT was determined again after NTG was infused for 20 minutes.RESULTS:
In group 1, the DFT (402 +/- 33V, 11 +/- 2J) was not different from the control (404 +/- 28V, 11 +/- 2J). In group 2, the DFT (521 +/- 18V, 19 +/- 1J) was higher (p < 0.004) than that in the control group (444 +/- 31V, 14 +/- 2J). Saline did not alter the DFT either individually or in combination with NTG.CONCLUSION:
Supratherapeutic dose of sildenafil-NTG combination significantly increased the DFT (17% of peak voltage, 37% of total energy). This effect on DFT appears to be driven by sildenafil and not NTG.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Inibidores de Fosfodiesterase
/
Piperazinas
/
Purinas
/
Sulfonas
/
Suínos
/
Fibrilação Ventricular
/
Cardioversão Elétrica
/
Nitroglicerina
/
Ventrículos do Coração
/
Hemodinâmica
Idioma:
Inglês
Ano de publicação:
2007
Tipo de documento:
Artigo
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