Pneumocystis pneumonia: an update.
Artigo
em Inglês
| IMSEAR
| ID: sea-42822
ABSTRACT
Pneumocystis pneumonia is a major cause of illness and death in immunocompromised hosts. The numbers of pneumocystis pneumonia cases in Thailand have increased each year from 1992 to 2000 and peaked in 2000 at 6,255 cases. The microbe that causes pneumocystis pneumonia in humans is called Pneumocystis jirovecii. Pneumocystis sp. was discovered nearly a century ago, but the knowledge of Pneumocystis sp. remained poorly understood, until the molecular biology techniques help scientists verify it fungus nature. In the past, Pneumocystis sp. was misclassified as protozoan due to its morphologic features. Later, it was reclassified as fungus due to DNA analysis. Cotrimaxazole, the combination of trimethoprim-sulfamethoxazole, is the drug of choice for treatment and prophylaxis of pneumocystis pneumonia. However, increasing evidence of mutations in the enzyme dihydropteroate synthase (DHPS), the target of sulfa drugs represent emergence of sulfa resistance.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pneumocystis
/
Pneumonia por Pneumocystis
/
Tailândia
/
Humanos
/
Resistência Microbiana a Medicamentos
/
Combinação Trimetoprima e Sulfametoxazol
/
Pneumocystis carinii
/
Genótipo
/
Estágios do Ciclo de Vida
/
Animais
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2004
Tipo de documento:
Artigo
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