ADC measurements in various patterns of multiple sclerosis lesions.
Artigo
em Inglês
| IMSEAR
| ID: sea-42931
ABSTRACT
OBJECTIVE:
To determine the difference of mean apparent diffusion coefficients (ADC) among different patterns of focal multiple sclerosis (MS) lesions, to compare mean lesion ADC between 2 clinical subgroups and to correlate mean lesion ADC with disability. MATERIAL ANDMETHOD:
Thirty seven patients (26 with relapsing-remitting multiple sclerosis (MS) and 11 with secondary-progressive MS) underwent both conventional and diffusion-weighted MR imaging of the brain. After creating ADC maps, region identification was done by using b = 0 images and T2-weighted images. ADC values were measured for MS lesions and (NAWM).RESULTS:
A total of 288 lesions were identified on the images. The mean ADC for the lesions was significantly higher than that of NAWM Hypointense T1 lesions (n = 221) had a significantly higher mean ADC than isointense T1 lesions (n = 67) in both nonenhancing lesions (n = 250) and enhancing lesions (n = 38). The enhanced rim of ring-enhancing lesions (n = 18) had lower ADC than the central nonenhanced portions. Confluent lesions (n = 62) had a substantially higher mean ADC than discrete lesion (n = 226). Mean lesion ADC of secondary progressive MS was significantly higher than relapsing remitting MS. No correlation between mean lesion ADC and (EDSS) score was foundCONCLUSION:
Quantitative diffusion-weighted imaging is useful to elucidate the heterogeneous pathological substrate of MS in different patterns of MS lesions, to differentiate 2 major clinical subgroups.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Índice de Gravidade de Doença
/
Feminino
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Humanos
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Masculino
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Intervalos de Confiança
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Fatores Sexuais
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Estudos Retrospectivos
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Estudos de Coortes
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Seguimentos
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Sensibilidade e Especificidade
Tipo de estudo:
Estudo diagnóstico
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Estudo de etiologia
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Estudo de incidência
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Estudo observacional
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Estudo prognóstico
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Fatores de risco
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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