Fatal adenovirus infections in infants probably infected with HIV.
Artigo
em Inglês
| IMSEAR
| ID: sea-43073
ABSTRACT
Adenovirus infections occur commonly in infants and children but are rarely fatal. Although immunosuppression has been associated recently with fatal outcome of adenovirus infections, reports of major morbidity or mortality caused by adenovirus infection in HIV positive patients are infrequent. This is the first report on fatal adenovirus infections in presumably HIV-positive infants in Thailand. Three infants, aged 4, 8 and 5 months, were hospitalized with diagnoses of pneumonia and ARDS, pneumonia with hepatomegaly and ARDS, and pediatric AIDS with pneumonia, respectively. All the infants died within a few weeks after hospitalization. Serologic tests revealed positive anti-HIV in all three infants. Unfortunately, no additional investigation for definite diagnosis of HIV infection was employed. Pathological findings from autopsy and post mortem needle biopsies revealed adenovirus pneumonia in the first two infants, and massive adenovirus infection of the liver in the third infant. Diagnoses were based on characteristic light microscopic pathological findings, and demonstration of viral particles arranged in crystalline arrays in the nucleus of the infected cells by electron microscopy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pneumonia Viral
/
Feminino
/
Humanos
/
Masculino
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Microscopia Eletrônica
/
Infecções por Adenovirus Humanos
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Infecções Oportunistas Relacionadas com a AIDS
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Histocitoquímica
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Lactente
/
Hepatopatias
Idioma:
Inglês
Ano de publicação:
1998
Tipo de documento:
Artigo
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