Effects of antileukotriene among asthmatic patients.
Artigo
em Inglês
| IMSEAR
| ID: sea-43431
ABSTRACT
STUDY OBJECTIVE:
To determine the effect of antileukotriene (montelukast) 10 mg once daily for the treatment of mild to moderate asthma.DESIGN:
Open label, prospective. PATIENTS Thirty asthmatic patients > or = 18 years of age with baseline FEV1 > 60 per cent and < or = 80 per cent of predicted values and evidence of reversible airway obstruction, as defined by an increase in FEV1 of > or = 20 per cent.INTERVENTIONS:
Montelukast 10 mg once daily orally for 12 weeks, back up beta-2 agonist inhaler was available. MEASUREMENT ANDRESULTS:
Spirometry was performed during the screening period, and every month after starting antileukotriene. Subjects recorded asthma-related symptoms and use of supplement beta-2 agonists daily on diary cards. Over 12 weeks of treatment, the FEV1 increased 10 per cent, 14 per cent and 19 per cent respectively, compared to the baseline (p < 0.05). The physician and patients evaluation scores were quite good in the study.CONCLUSION:
Oral montelukast once daily gave a favorable effect in management of mild to moderate asthmatic patients.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Quinolinas
/
Asma
/
Espirometria
/
Idoso
/
Humanos
/
Administração Oral
/
Estudos Prospectivos
/
Resultado do Tratamento
/
Antiasmáticos
/
Adulto
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2001
Tipo de documento:
Artigo
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