Thyroid function in beta-thalassemic children receiving hypertransfusions with suboptimal iron-chelating therapy.
Artigo
em Inglês
| IMSEAR
| ID: sea-43750
ABSTRACT
A cross-sectional study of thyroid function, free thyroxine (FT) and thyrotropin (TSH) concentrations, was carried out in 51 transfusion-dependent beta-thalassemic patients receiving suboptimal iron-chelating therapy. Nine patients had normal FT4 levels with elevated TSH levels (5.9-15.6 mLU/L), consistent with the diagnosis of compensated primary hypothyroidism and giving a prevalence of abnormal thyroid function of 17.6%. All patients with abnormal thyroid function had negative thyroid antibodies. No particular risk factor for abnormal thyroid function could be identified. Of the nine patients with compensated primary hypothyroidism, one patient showed a further increase in TSH level after 1 year of follow-up. The results of the present study emphasize the importance of thyroid function monitoring in hypertransfused beta-thalassemic patients.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Doenças da Glândula Tireoide
/
Glândula Tireoide
/
Tiroxina
/
Transfusão de Sangue
/
Feminino
/
Humanos
/
Masculino
/
Tireotropina
/
Criança
/
Quelantes de Ferro
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Ano de publicação:
2007
Tipo de documento:
Artigo
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