Ondansetron vs. metoclopramide for the prevention of nausea and vomiting after gynecologic surgery.
Artigo
em Inglês
| IMSEAR
| ID: sea-43828
ABSTRACT
BACKGROUND:
Postoperative nausea and vomiting (PONV) remains a very troublesome concomitant phenomenon after general anesthesia. The present study was designed to compare the efficacy and safety of ondansetron with metoclopramide for prophylaxis of PONV in patients undergoing major gynecological surgery. MATERIAL ANDMETHOD:
A prospective, randomized, double-blind, 382 female patients received either ondansetron 4 mg or metoclopramide 10 mg intravenous administration immediately before the induction of anesthesia. A standard general anesthetic technique was employed throughout. Nausea, vomiting, and safety assessments were performed continuously during the 24 h postoperative period.RESULTS:
Of the 380 patients evaluated, significantly fewer ondansetron 4 mg treated patients (89/189; 47%) experienced postoperative nausea and/or vomiting compared with metoclopramide treated patients (115/ 191; 60%) during the study period (p = 0.007, 95% CI 1.07, 1.66). Postoperative adverse events were not significantly different between the groups.CONCLUSION:
Prophylactic use of ondansetron is more effective than metoclopramide for preventing PONV in patients undergoing major gynecological surgery.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Complicações Pós-Operatórias
/
Procedimentos Cirúrgicos em Ginecologia
/
Vômito
/
Idoso
/
Feminino
/
Humanos
/
Método Duplo-Cego
/
Estudos Prospectivos
/
Ondansetron
/
Adulto
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Idioma:
Inglês
Ano de publicação:
2008
Tipo de documento:
Artigo
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