TNF alpha and NRAMP1 polymorphisms in leprosy.
Artigo
em Inglês
| IMSEAR
| ID: sea-43850
ABSTRACT
OBJECTIVE:
To determine the association of TNF alpha and NRAMP1 polymorphisms in leprosy. MATERIAL ANDMETHOD:
The polymorphisms of TNF alpha at -238, -308, and NRAMP1 at INT4, D543N, and3' UTR were examined in 37 patients with leprosy (24 multibacillary and 13 paucibacillary) and 140 healthy controls. PCR-SSP and PCR-SSO method were used to type TNF and NRAMP1 polymorphisms.RESULTS:
The genotype frequency of TNF-308 G/A was significantly increased in all leprosy patients compared to the controls (p = 0.04, OR = 2.69). When leprosy types were divided, the allele frequency of TNF-308A was significantly increased in multibacillary leprosy compared to the normal controls (p = 0.04, OR = 2.93). There was no significant difference in the distribution of the genotypes and allele frequencies of TNF -238 and NRAMP1 polymorphisms between the patients and controls.CONCLUSION:
TNF-308A was associated with susceptibility to multibacillary leprosy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polimorfismo Genético
/
Tailândia
/
Humanos
/
Estudos de Casos e Controles
/
Fatores de Risco
/
Fator de Necrose Tumoral alfa
/
Proteínas de Transporte de Cátions
/
Suscetibilidade a Doenças
/
Alelos
/
Genótipo
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2007
Tipo de documento:
Artigo
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