Thrombophilia profile in Thai patients with arterial thrombotic disorders.
Artigo
em Inglês
| IMSEAR
| ID: sea-44324
ABSTRACT
BACKGROUND:
Arterial thrombosis is attributed mainly to atherosclerosis and the roles of hypercoagulability remain unclear In addition, there are ethnic variations in thrombophilia profiles.OBJECTIVE:
The authors performed a survey of the thrombophilia profile in Thai patients with arterial thrombosis MATERIAL ANDMETHOD:
The authors analyzed 103 consecutive cases of proven arterial thrombosis and requested thrombophilia profile in Chulalongkorn Hospital during 2003-2004. The mean age was 42.5 years. The proportions of stroke, peripheral arteries, and other sites were 70.9%, 22.3% and 6.8%, respectively.RESULTS:
Abnormal profile was found in 35.0% with the prevalence of hyperhomocysteinemia, low protein S, antiphospholipid antibody and low protein C was 15.5%, 12.6%, 9.7%, and 5.8%, respectively. There was no difference in clinical characteristics between cases with or without detectable abnormalities. However, the authors found significant associations of low protein S with poor outcome and HIV seropositivity with antiphospholipid.CONCLUSION:
The present study found that the defective protein C pathway may be the most common thrombophilia found in Thais with arterial thrombosis. Future study is required to prove the cause-effect relationship and its clinical significance.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Arteriopatias Oclusivas
/
Tailândia
/
Trombose
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Razão de Chances
/
Criança
/
Pré-Escolar
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS