Comparison of topical prednisolone acetate, ketorolac tromethamine and fluorometholone acetate in reducing inflammation after phacoemulsification.
Artigo
em Inglês
| IMSEAR
| ID: sea-44651
ABSTRACT
AIMS:
To compare the efficacy and ocular adverse effects of topical prednisolone acetate, ketorolac tromethamine, and fluorometholone acetate in reducing inflammation after phacoemulsification.METHOD:
One hundred and twenty eyes were enrolled in a prospective, investigator-masked, randomized controlled trial. Each drug was prescribed 4 times a day for 28 days. The following data were recorded weekly visual acuity, intraocular pressure, slit lamp biomicroscopy, grading of cells and flare in the anterior chamber, and ocular symptoms.RESULTS:
The number of eyes with a minimal amount of cells in the anterior chamber in the ketorolac group was less than the prednisolone group on day 7 (1120, p = 0.008) and day 14 (2331, p = 0.015), and than fluorometholone group on day 7 (1121, p = 0.011). Intraocular pressure in the prednisolone group was higher than the ketorolac group on day 21 (14.612.2 mmHg, p = 0.016). One eye in the prednisolone group had intraocular pressure of 32 mmHg. Burning sensation was reported frequently in the ketorolac group.CONCLUSION:
All 3 drugs were effective in reducing post-operative inflammation. The efficacy of prednisolone acetate and fluorometholone acetate was comparable. Ketorolac tromethamine showed less efficacy than corticosteroids, however, it did not induce ocular hypertension.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Complicações Pós-Operatórias
/
Valores de Referência
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Idoso
/
Feminino
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Humanos
/
Masculino
/
Esquema de Medicação
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Fluormetolona
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Prednisolona
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Distribuição de Qui-Quadrado
Tipo de estudo:
Ensaio Clínico Controlado
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Estudo de etiologia
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Estudo observacional
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Estudo prognóstico
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Fatores de risco
Idioma:
Inglês
Ano de publicação:
2003
Tipo de documento:
Artigo
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