Granulocyte-colony stimulating factors for secondary prevention of leucopenia in patients receiving chemotherapy.
Artigo
em Inglês
| IMSEAR
| ID: sea-45188
ABSTRACT
OBJECTIVE:
To evaluate the effectiveness of GCSF as a secondary preventive adjunct to chemotherapy in the gynaecologic cancer patients who previously had grade 3-4 neutropenia or leucopenia from chemotherapy. MATERIAL ANDMETHOD:
We retrospectively reviewed the medical records of 94 chemotherapeutic cycles with GCSF as secondary prophylaxis in 29 patients with gynaecologic malignancy between January 1996 and April 2005.RESULTS:
The median age of the patients was 51 years (21-75). Most of the patients had ovarian cancers (19 cases, 65.6%). From secondary GCSF, grade 4 neutropenia was developed in 12 of 94 cycles (12.8%), and grade 4 leucopenia was developed in 5 of 94 cycles (5.3%). There were no patients developing febrile neutropenia after GCSF support.CONCLUSION:
Secondary GCSF prophylaxis was effective in preventing grade 4 leucopenia, grade 4 neutropenia, and febrile neutropenia.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias Ovarianas
/
Idoso
/
Feminino
/
Humanos
/
Fatores de Risco
/
Carboplatina
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Cisplatino
/
Paclitaxel
/
Adulto
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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