Effectiveness of nicotinic acid and bezafibrate alone and in combination for reducing serum triglyceride level.
Artigo
em Inglês
| IMSEAR
| ID: sea-46504
ABSTRACT
OBJECTIVE:
To study the effectiveness of nicotinic acid and Bezafibrate alone and in combination for reducing triglyceride level.DESIGN:
It was a randomised, prospective, longitudinal study.SETTING:
Patients attending a private clinic, and medical department of Kathmandu Medical College, Sinamangal.METHODS:
This study included 83 consecutive patients, 19 females and 64 males with hypertriglyceridaemia (defined as serum triglyceride >200mg/dl) attending the department of medicine, Kathmandu Medical College, Sinamangal and private clinic. MAIN OUTCOMEMEASURES:
Statistically significant reduction of serum triglyceride level.RESULT:
51 out of 83 patients completed the study in which Nicotinic acid alone reduced the serum trygleceride level from 320.62 +/- 104.23 to 182.55 +/- 46.21, which is a reduction of 138.07 +/- 85.69 (P. value = 001). Bezafibrate when given alone also reduced triglyceride level significantly from 345.25 +/- 181.03 to 203.30+/-93.59 which is a reduction of 141.95 +/- 121.130 (P value= .001). When a combination of both drugs was given the reduction of 472.73+/-247.53 (P value =.002) was achieved.CONCLUSIONS:
Nicotinic acid is a very effective drug in reducing serum triglyceride level and its effectiveness is similar to Bezafibrate. There is no added benefit of giving a combination of nicotinic acid and Bezafibrate in reducing serum triglyceride level.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Triglicerídeos
/
Bezafibrato
/
Feminino
/
Humanos
/
Masculino
/
Hipertrigliceridemia
/
Resultado do Tratamento
/
Quimioterapia Combinada
/
Hipolipemiantes
/
Niacina
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Idioma:
Inglês
Ano de publicação:
2005
Tipo de documento:
Artigo
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